Clinical Implications
This preliminary study may help us to understand the genetic basis of delusional disorder and
paranoid schizophrenia.
This investigation may further help in understanding whether delusional disorder and paranoid
schizophrenia bear similar etiologic mechanisms based on HLA associations.
The study may strengthen our knowledge of the paranoid spectrum concept.
Limitations
The sample size was small, and the study needs to be replicated in a large sample.
We studied the distribution of HLAs in delusional disorder as a whole, rather than by subtype.
We did not study the familial clustering pattern of these HLA genes.