Although various
subgroup analyses were done to elucidate the
heterogeneity, insuffi cient data were available to analyse
the eff ect of frequency of antiseptic application, its form,
or whether teeth were brushed in combination with the
intervention. Although it can be assumed that
combination of diff erent interventions for oral care
might act synergetically, further research is needed to
identify their specifi c attributable benefi t on the
prevention of the disease