Contra-indications. Breeding animals Side-effects. Keratoconjunctivitis sicca; decreased tear production; vomiting; diarrhoea; stiffness; pruritus; mucocutaneous erythema; elevation of serum-cholesterol, -triglycerides, -aspartate aminotransferase, -alkaline phosphatase, and -alanine aminotransferase concentrations Warning. Monitor changes in haematology, blood biochemistry, urine and tear production; female operators should take care when handling the product Dose. Dogs: by mouth, 0.5–1.0 mg/kg once daily, given with food