The large majority of nerve fiber
connections passing through the corpus callosum are established before birth, and the experience-dependent pruning and elimination of fibers
through this region continue into adolescence [43], which is a critical
period for the development of schizophrenia. Considering the role that
NgR and its co-factor signaling partners have in myelin-related processes,
and that a number of studies have shown strong associations
between negative childhood experiences and adult psychiatric illnesses
in addition to alterations in myelinated regions of the brain [19,44–46];
it seems reasonable to speculate that these genes may prove useful in
understanding the mechanism by which negative experiences early in
life can affect myelin-related processes in the context of schizophrenia.