This work aimed to evaluate the efficiency of different organic solvents such as, methanol, ethanol,
dichloromethane, acetone, hexane and ethyl acetate for extraction of ( flavonoids and polyphenolic
compounds(TFC and TPC respectively) from the orange peel. Also, the effect of these solvents on the yield
percentage, chelating activity, antioxidant/radical scavenging capacity and reducing power ability of the
produced extracts were investigated. The results revealed that all extracts of the orange peel exhibited variable
antioxidant activity. Specially, the ethanolic extract showed the highest (p < 0.05) values for yield (%), TPC,
TFC, chelating and antioxidant activities (% DPPH scavenging activity). It is concluded that, the solvent play
a vital role in the extraction of the plant constituents. Specially, methanol and ethanol are high polar among the
solvents used.