Historically, the existing armamentarium
of antiacne agents has included
topically applied or systemically
administered antimicrobials or
retinoids. The ideal agent would target
each of the pathogenic factors
without producing adverse effects;
however, the antiacne agents currently
available target only 1 or 2 of
the pathogenic factors. Apart from
isotretinoin, there is no agent with
broad spectrum action in acne. There
is a clear-cut need for new, safe, and
effective agents in the treatment of
acne.