The experiments showed the feasibility of using active microorganisms immobilized on mineral carriers for the removal of malodorous compounds from poultry manure. The most active strains in the PM deodorization turned out to be B. subtilis subsp. spizizenii, L. mesenteroides, C. inconspicua, and P. faecalis and the highest effectiveness was reported in the removal of ammonia and hydrogen sulfide from exhaust gas. Microorganisms changed the chemical composition of poultry manure) during deodorization (mainly nitrogen compounds, including proteins and amino acids. In particular, the mixed culture was active against cysteine and methionine, which were removed from PM by around 45% within 24 h of deodorization.