From Denki virus infectionFound that during the first days of infection, WBC type granule decreased was found and after 3-4 days, Lymphoid and monocyte increased most atypical lymphocyte Lymphoid and monocyte secrete cytokinas and mediators such as anaphylatoxin C3a, C5a.Resulting in endothelil injury and activation coagulation resulting in DICIf DIC not treatment causes shock and death