the decrease in the concentration of Cl in the femur of pigs
fed benzoic acid in the present study reflected the drastically
increased urinary excretion of Cl.
The decrease in the concentration
of Cl in bone ash might be partially due to a
repartitioning into other tissues and fluid spaces such as
interstitial fluid or connective tissue. In contrast, metabolic
acid load in growing swine can also alter Cl retention (Budde
and Crenshaw, 2003), while not affecting the urinary excretion
of Cl. The losses of Cl in urine observed in the present
study but not in the study by Budde and Crenshaw (2003)
may indicate an adaptive renal response to benzoic acid. More
specifically, the influence of enhanced H+ that is derived from
benzoic acid may directly alter the renal compensatory
mechanism driven towards maintenance of plasma pH.
Given that bone weight and Ca concentration in bone ash
were affected by benzoic acid, a change in bone resorption
induced to buffer the increase in acid absorption is likely. If
one considers that the normal resorption of AA from the
glomerular filtrate is associated with cotransport of Na, a
conjugation of free glycine with benzoic acid may have
indirectly increased Na excretion in urine of the pigs fed the
benzoic acid-containing diets. Furthermore, the increased
urinary Cl excretion is likely a result of several other physiological
adaptations including the increased urinary Na loss,
the increased H+ concentration in the distal tubules, and the
increased bicarbonate resorption; however, the latter two
were not measured in the present study. Therefore, the
reduction in Cl concentration in the femur of pigs fed the
benzoic acid-containing diets in this study is likely a direct
reflection of the increased urinary excretion of Cl which in
itself reflects the new homeorrhetic mineral balance established
by these diets.
the decrease in the concentration of Cl in the femur of pigsfed benzoic acid in the present study reflected the drasticallyincreased urinary excretion of Cl. The decrease in the concentrationof Cl in bone ash might be partially due to arepartitioning into other tissues and fluid spaces such asinterstitial fluid or connective tissue. In contrast, metabolicacid load in growing swine can also alter Cl retention (Buddeand Crenshaw, 2003), while not affecting the urinary excretionof Cl. The losses of Cl in urine observed in the presentstudy but not in the study by Budde and Crenshaw (2003)may indicate an adaptive renal response to benzoic acid. Morespecifically, the influence of enhanced H+ that is derived frombenzoic acid may directly alter the renal compensatorymechanism driven towards maintenance of plasma pH.Given that bone weight and Ca concentration in bone ashwere affected by benzoic acid, a change in bone resorptioninduced to buffer the increase in acid absorption is likely. Ifone considers that the normal resorption of AA from theglomerular filtrate is associated with cotransport of Na, aconjugation of free glycine with benzoic acid may haveindirectly increased Na excretion in urine of the pigs fed thebenzoic acid-containing diets. Furthermore, the increasedurinary Cl excretion is likely a result of several other physiologicaladaptations including the increased urinary Na loss,เพิ่ม H + ความเข้มข้นใน tubules กระดูก และไบคาร์บอเนตเพิ่มขึ้น resorption อย่างไรก็ตาม สองหลังมีวัดในการศึกษาปัจจุบัน ดังนั้น การลดความเข้มข้น Cl ในกระดูกต้นขาของสุกรที่เลี้ยงในอาหารที่ประกอบด้วยกรด benzoic นี้ศึกษาน่าจะเป็นตรงภาพสะท้อนของการขับถ่ายท่อปัสสาวะที่เพิ่มขึ้นของ Cl ซึ่งในตัวเองสะท้อนให้เห็นถึงการ homeorrhetic แร่ยอดดุลใหม่ก่อตั้งขึ้นโดยอาหารเหล่านี้
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