Antibiosis refers to the adverse effect of host plant on the development and reproduction of insect pests which feed on resistant plant. Resistant plants retard the growth and rate of reproduction of insect pest. In some cases, antibiotics may lead even to death of an insect. An antibiotic is considered as the true form of resistance to insect pests. In cotton, antibiotics is related with high level of gossypol, tannins , heliocides and silica contents, antibiotics may involve morphological , physiological and biochemical features of the host plant.