This study aimed to first investigate the immuno-modulatory effects of six newly isolated lactic acid
bacteria (LAB) on the peripheral blood mononuclear cells (PBMC) of Wistar rats. Except for Lactobacillus
plantarum TN8, all the other strains were noted to induce high levels of pro-inflammatory cytokine IL-12
and low levels of anti-inflammatory cytokine IL-10. The strains also generated low ratios of IL-10/IL-12
cytokine. Strain TN8 was, on the other hand, noted to induce an increase in anti-inflammatory IL-10
cytokine secretion rates and a decrease in pro-inflammatory IL-12, IFN-g and TNF-a cytokine production.
The oral administration of TN8 improved the hepatic and urinary functions of obese rats by inducing
decreases (P < 0.05) in alanine amino transferase (ALAT), gamma glutamyl transferase (GGT), plasmatic
triglycerides, total cholesterol concentrations, creatinine, urea, and body weight when compared to the
control group of animals that underwent an increase in aspartate amino transferase (ASAT) and high
density lipoprotein (HDL). Overall, the findings indicate that strain TN8 exhibited a number of attractive
properties that might open new promising opportunities for the improvement of various parameters
related to animal health performance and the avoidance of antibiotics and drugs as promoting factors