Consistent with the strong association between overall
medical morbidity and major depression, three specific
Charlson Comorbidity Index medical conditions had significantly higher rates of major depression when we controlled for age and gender (Table 3): diabetes with end-organ compromise (adjusted odds ratio=4.11, 95% CI=2.13–
7.91), history of myocardial infarction (adjusted odds ratio=2.35, 95% CI=1.38–3.99), and peripheral vascular disease (adjusted odds ratio=2.18, 95% CI=1.28–3.73). When
statistical significance was set at p