There is scarce data regarding HPV distribution in ICC in the Portuguese population [6] and [7]. Large international series demonstrate that, although a small number of different types are more prevalent than others, there are some geographical differences regarding HPV type distribution [8]. Our aim was to describe the HPV genotype distribution in ICC in Portugal, to analyze differences in along nine decades (from 1928 to 2005). This study is part of a larger study, RIS HPV TT study [9], whose objective was to describe the HPV genotype distribution in invasive cervical cancer worldwide.