46:33
35 pounds and mike got ya impact of thank you
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out and show you he's brought me to meet beekeeper Ted jansen
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to get a close-up look it the inspiration behind the science
46:44
now see here's one Sorenstam what budget aren't you say our something
46:49
know that I hush the that a little
46:53
menem'sharpootlian it's not posting her that her 2001
46:58
a bee sting may seem like a minor irritation
47:01
but actually the venom is extremely toxic to cells
47:04
immediately when yet another p.m. stops so why would it have been badly to just
47:09
pack it out
47:09
because you squeeze ha and squeeze on them always seems
47:14
me so Sam you're not here to see any kind now we like to be is because they
47:18
make a toxin toxins Malott
47:20
music to specifically treat cancers the venom
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a cancer drug yes be venomous attacks on cancer has been known for quite some
47:28
time but the problem is how to deliver a
47:30
mountain is not being used yet to fight cancer
47:34
because it will destroy any celeb unscented including healthy ones
47:39
but realizing its potential Sam set out to engineer a nano-scale robot
47:44
to carry the toxins safely through the body in releasing only when it finds its
47:49
target
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not surprisingly he causes invention
47:53
nano beads
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each now be has three parts: so what we've got here
47:59
as model Sam explains with a simple demonstration of how they fit together
48:05
miss basically is a spear carbon fluorine atoms that forms the carrier
48:09
for that melham the center banana be
48:13
is the nanoparticle constructed out of several thousand
48:16
carbon and fluorine atoms arranged in a spherical
48:19
hoster less than three hundred nanometers in diameter
48:23
and then now we have a coating on that which is a fatty kinda accounting
48:29
and this patty coating allows us
48:32
you insert the militant toxin
48:35
internist article here they would be all over this exactly
48:39
this outer layer holds the deadly be poisoned in place
48:43
it's like a holster that keeps a gun safe until its strong
48:46
every tumor cell has a distinct chemical makeup
48:50
the out earlier banana be is programs to selectively lock onto
48:54
only those cells that need to be destroyed so
48:58
of you take this balloon as a cancer cell this nanoparticle will come up next
49:03
in a cancer cell
49:04
basically merge with it the coding come off
49:08
and the militant itself forms a hole in the cancer cell and pops
49:13
like its namesake banana be in staying
49:16
only once so swarms of them are required for any treatment
49:20
Sams lab has decoded the chemical makeup of the the venom
49:25
so he can manufacture in large quantities for his now be swarms
49:31
I say goodbye to our beekeeping hosts
49:34
in order to pay a visit to Sams lab Washington University
49:38
to see how the Nano bees work in the body so here we are
49:42
magnetic resonance imaging suite I'm gonna show you what it's like to be a
49:45
patient
49:46
as if we were looking for nano these insider and managers say
49:50
would boost disc is my dignity to wear a sundress and slide into a giant
49:54
beagle Moscow toast you an MRI
49:58
uses strong magnetic field in radio waves to detect certain molecules in the
50:03
body
50:03
this machine has been tuned to detect chlorine atoms
50:08
which are part banana be molecules butter
50:11
otherwise very rare in the body okay having fun in there yet
50:16
wrong he did
50:21
play example actually injected Nana bees into me
50:25
and if I had the cancer that they'd been trained to fight conc
50:30
it would travel in my bloodstream and stick to any target tissue the encounter
50:34
images that the technicians see which job right
50:37
yellow areas where the individual man abuse for finding and killing the
50:41
disease itself
50:43
investorpaul there be no toxic side effects as with traditional chemotherapy
50:48
Sam way week from he's in every day
50:52
human cancer patients well now this materialize
50:56
being tested in what's called preclinical stage
50:59
and we hope that within about a year or so that will have approval to test this
51:04
in humans
51:05
thanks and I appreciate this experiment typically how long would you
51:10
nation lying in this to guys
51:14
guys like the nanoscale transistors that came before them
51:24
nano bees get their power from their tiny size
51:28
banana bees and other emerging nanotechnologies go even further
51:32
so this is where militants meet now bees are part of a new breed of small
51:37
materials
51:38
itself a sample no need for big complicated machinery to make nano bees
51:43
put the rating greedy is together in the right conditions
51:46
and they make themselves
51:49
this revolution in medicine working at the tiniest have scales
51:53
would never have been possible without the revolution in electronics
51:57
that preceded both are transforming our world.
52:01
and our lives an astonishing speed as we see the power in this new ability to
52:06
design and build
52:07
Adam by Adam there may be no more important goal
52:11
in the sciences materials and mastering the art
52:14
making stock small but
52:23
can we make stuff cleaner and greener biodegradable plastics we've gone from
52:29
this service a new approach to fuel cell cars
52:33
here it is folks the future American hydrogen storage
52:36
hold David Pogue investigate new materials on the cutting edge
52:40
clean things like a scene from Willy Wonka look at
52:43
for the soybean seat cushions are performing well
52:48
forty miles an hour making stuff clear
52:51
next time on over
53:11
this novel program is available on DVD and Blu ray
53:14
at shop PBS star torque or call one eight hundred
53:18
play PBS
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the
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the
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the