Anti- arthritic activity
Jagan et al29 had reported the anti-arhtritic activity of petroleum-ether extract of Portulaca oleracea Linn by Fruends adjuvant arthritis model in
male wistar rats. The test extracts were at the dose of 100,200 and 300 mg/kg/p.o and standard as Indomethacin at a dose of 100mg/kg. A maximum of
77.82% inhibition was observed on 21st day. In a similar fashion treatment with petroleum ether extract also attenuated the increase in paw diameter due to
Fruends adjuvant administration, this was more pronounced at 300mg/kg of petroleum ether extract of portulaca oleracea. A maximum of 75.69% inhibition
was observed on 21st day. This study revealed the anti-arthritic activity of aqueous extract of portulaca oleracea.
3.7 Anti- diabetic activity
An et al5
had reported the anti diabetic activity in aqueous extract of portulaca oleracea in rosiglitazone induced diabetics . P.oleracea treatment
markedly lowered blood glucose, plasma triglyceride, plasma level of LDL- cholesterol and systolic blood pressure in diabetic mice. Furthermore, Portulaca
oleracea significantly increased plasma level of HDL-cholesterol and insulin level. The impairment of Ach and SNP- induced vascular relaxation of aortic
rings were ameliorated by PO treatment in diabetic db/db mice and it also showed that over expression of VCAM-1, ICAM-1, E-selectin, MMP-2 and ET-1
were observed in aortic tissues of untrated db/db mice, which were significantly suppressed by treatment with PO. In this study, it was found that the
immune reactivity of the pancreatic islets remarkably increased in treated diabetic mice compared with untreated diabetic mice. Thus they concluded that PO
suppresses the hyperglycemia and diabetic vascular inflammation, and prevents the development of diabetic endothelial dysfunction for the development of
diabetes and its vascular complications.