could compete for the αvβ3 sites on the cell membrane and
reduce the access of DOX-loaded DOX@MSN-
GFLGR7RGDS/α-CD to αvβ3 overexpressed HeLa cells,
further confirming that the internalization of the nanoparticles
was achieved via receptor-mediated endocytosis. We believe
that the multifunctional MSNs demonstrated here can be used
as a versatile nanoplatform for targetedly delivering therapeutic
drug for cancer therapy. Considering the large size of designed
MSNs in this study, a drug delivery system based on smaller
MSNs is being constructed at present for in vivo anticancer
therapy in further study.