Trypanosoma brucei brucei is limited to animals and non-infective to humans due to trypanolytic factors found in human serum, whereas other two subspecies responsible for human trypanosomiasis, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, have developedmechanisms for escaping from lysis mediated by the trypanosome lytic factor (TLF) (Lugli et al., 2004; Wheeler, 2010), which is primarily composed of Apolipoprotein L1 (ApoL1) and a haptoglobin-related protein (Raper and Friedman, 2013).