Hill et al. performed abdominal MRI in 46 patients with Gaucher disease using T1- and T2-weighted images [10]. Splenic nodules were detected in 14 of 46 patients (30%), appear- ing isointense on T1-weighted images and hypointense on T2-weighted images [10]. In eight of these 14 patients, splenic nodules appeared hyperintense on T2-weighted images, comparable to the signal pattern of a few splenic nodules in the present case. In the study by Hill et al., pathologic correlation was performed with specimens from two patients who underwent partial splenectomy. The resected specimen of one patient contained wedge- shaped subcapsular areas of extensive infarction. The other specimen contained red and white nodules that differed in diameter from 0.5 to 2.5 cm. Microscopically, the red nodules contained collections of Gaucher cells and dilated sinusoids filled with blood. The white nodules were composed of only Gaucher cells. Hill et al. assumed that the hyperintense nodules on T2-weighted images corresponded to the red nodules and to dilated sinusoids. The hypointense nodules were thought to correspond with the white nodules and sheets of Gaucher cells [10]. In comparing our findings with those of Hill et al., most of the splenic nodules appeared hypointense on T2-weighted images, suggesting sheets of Gaucher cells. Neither a subcapsular infarction nor a targetlike appearance of splenic nodules was detectable in our patient.