Essential Hypertension Initially 12.5 mg once daily for 1st 2 days. Maintenance: 25 mg once daily. May increase at 2-wk intervals to administration total daily dose of 50 mg once daily or in divided doses. Angina pectoris Initially 12.5 mg twice daily for 1st 2 days. Maintenance: 25 mg twice daily. May increase at 2-wk intervals to a total daily dose of 100 mg in divided doses. Symptomatic chronic heart failure Initially 3.125 mg twice daily for 2 wk. May increase at 2-wk intervals to 6.25 mg twice daily followed by 12.5 mg twice daily & 25 mg bid thereafter. Patient >85 kg Max: 50 mg twice daily, 1 wk, recommence at 3.125 mg twice daily & titrate dose accordingly