Fig. 3. Electrostatic potential surfaces were calculated in order to analyze and compare the charge distribution of the produced 3D model of the COXIIa and COXIIb complexes to its tem-
plate structure that was based on. The two complexes exhibited almost identical electrostatic surfaces, sharing common features that were not disturbed by the addition of the two extra
α-helices on the homology model. There is a hydrophobic, uncharged region in the mid section of the two complexes (depicted by white boxes) that is vital to its function that has been
conserved, despite the addition of the insert structures. This observation verified the validity of the model, which was found to share similar electrostatic surface of almost identical intensity,
to its X-ray determined template structure. The 3D position of the two extra α-helices is indicated by the square black boxes.