Discussion
Gastric cancer is one of the most common human malignant tumors. Epidemiological investigations have provided evidence that gastric carcinogenesis is a complex, multistep and multifactorial event (15). Considering that reactive oxygen species (ROS) are capable of changing a number of cellular events involved in the cancer process by which cancer cells escape the immune system, the status of oxidative stress and immunity response may be a crucial factor in the development of gastric cancer. Despite continuous progress in the development of conventional therapies such as surgery, chemotherapy, and radiotherapy, as well as novel target-protein-based cancer therapy, gastric cancer is still the second highest cause of cancer-related mortality, indicating that the value of these therapies in the management of tumors may have reached a plateau (16). Nutritional support is a recent advancement in the domain of diet-based therapies (17). As a formidable prophylactic and therapeutic medicinal food, garlic and its extracts are significant components of strategies to prevent and cure various malignancies (18,19). To investigate this potential connection, the antioxidant and immunopotentiating effects of ABGE on gastric cancer were examined in SGC-7901 cells in vitro and in a tumor-bearing mouse model in vivo, respectively.