Allicin prevented myocardial fibrosis in diabetic rats
As sensitive indicator of myocardial fibrosis, the expressions of
CTGF and TGF-1 protein are detected by immunohistochemical
staining with specific antibodies (Fig. 3). We here showed that CTGFand TGF-1 protein expression were increased in STZ-induced diabetes
rat hearts. Interestingly, all of these indicators of myocardial
fibrosis induced by diabetes were improved by AL (8 mg/kg and
16 mg/kg) in a dose-dependent manner. But, MET 100 mg/kg only
attenuated TGF-1 protein expression