In most model systems, the synthesis and level of cyclins are tightly regulated during the cell
cycle, with each cyclin being degraded via ubiquitination once its function is complete .
Key cell cycle transitions are regulated by specific cyclins: G1/S cyclins, which are essential for
cell cycle entry at G1/S (start), and G2/M cyclins, which are essential at the G2/M (mitosis)
transition. In some species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates
there are at least three G1 cyclins (C, D, and E) and two G2 cyclins (A, which is also
active in S phase, and B). Many other cyclins with additional functions have also been
described
In most model systems, the synthesis and level of cyclins are tightly regulated during the cellcycle, with each cyclin being degraded via ubiquitination once its function is complete .Key cell cycle transitions are regulated by specific cyclins: G1/S cyclins, which are essential forcell cycle entry at G1/S (start), and G2/M cyclins, which are essential at the G2/M (mitosis)transition. In some species, there are multiple forms of G1 and G2 cyclins. For example, in vertebratesthere are at least three G1 cyclins (C, D, and E) and two G2 cyclins (A, which is alsoactive in S phase, and B). Many other cyclins with additional functions have also beendescribed
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