In Bangladesh, the point prevalence of PUD is 15% (DU-11.98% and GU-3.58%), which is much higher than that in the developed countries (15% vs 1.5%). Over 95% (95-100%) of DUs and >80% (56-96%) of GU are strongly associated with H. pylori infection. However, for unknown reason although about 15% of the infected persons develop PUD many infected persons in Africa never develop PUD. A meta analysis of the several controlled clinical trials showed that H. pylori eradication therapy enhances a rapid ulcer healing at a higher rate and marked reduction in the recurrence rate of PUD particularly DU from 80 to 4% yearly. On this ground, NIH of America in 1994, European H. pylori study group in the Maastricht consensus conference 1996 and FDA of USA in 1998 recommended that all patients with endoscopically documented PUD with H. pylori infection should receive a course of anti-microbial therapy.