Discussion
Gastric cancer is one of the most common human malignant tumors. Epidemiological investigations have provided evidence that gastric carcinogenesis is a complex, multistep and multifactorial event (15). Considering that reactive oxygen species (ROS) are capable of changing a number of cellular events involved in the cancer process by which cancer cells escape the immune system, the status of oxidative stress and immunity response may be a crucial factor in the development of gastric cancer. Despite continuous progress in the development of conventional therapies such as surgery, chemotherapy, and radiotherapy, as well as novel target-protein-based cancer therapy, gastric cancer is still the second highest cause of extraction, can suppress growth of cancer cells of different anatomical locations and modulate a number of key elements in cellular signal transduction pathways related to the apoptotic process (22). In the tumor-bearing mouse model, administration of ABGE effectively suppressed the development of inoculated tumor cells, indicating that ABGE also plays an anticancer role in vivo. Several early studies focused on the analysis of the effects of treatment with garlic or its components on the tumorigenic capabilities of the inoculated tumor cells in test animals. In these studies, reduced tumor growth and increased survival were also observed (23,24).