Moderate intake of vitamin C may produce a hypocholesterolaemic effect which is not significantly different in males than in females. The action of vitamin C on cholesterol and other lipid profile parameters appears to be similar as far as gender is concerned. Thus, it may have protective action against atherosclerosis and may attenuate coronary heart disease (CHD) and long term supplementation of vitamin C may be used to keep the lipid profile within normal limits in both the sexes without any gender bias..