4. Conclusions
In conclusion, the methanol extract of Sedum sarmentosum (SS) possesses anti-angiogenic, anti-inflammatory and anti-nociceptive activities. It also possesses an inhibitory activity on NO production in the stimulated mammalian macrophage cells. It is capable of suppressing expression of iNOS in LPS-stimulated RAW264.7 cells. However, SS, at the used concentrations, had no effect on the expression of COX-2 in the stimulated macrophages. SS also contains a reducing activity on ROS level in LPS-activated macrophages. These findings offer novel pharmacological information on Sedum sarmentosum, which implies its plausible therapeutic role for some folk medicines. Sedum sarmentosum would be regarded as a starting point for the development of an anti-inflammatory drug with fewer side effects.