Glycolic acid (GA) is an alpha hydroxyl acid. Although there are several reports on the clinical effects of GA in rejuvenation, peeling, and photoaging, no data on the effectiveness of GA to prevent stretch marks could be found in the scientific literature. No epidemiological study on the use of GA in pregnant women has been published. One study comparing topical 20% GA and 0.05% tretinoin with 20% GA and 10%l-ascorbic acid found that both regimens improved the appearance of striae alba and showed no difference in effect from combining 10% ascorbic acid or 0.05% tretinoin with 20% GA, although it was not determined which of the ingredients provided the effect.39 The precise mechanism of action of GA is still unknown because the biological effects of GA on cells has not been fully studied, although GA is reported to stimulate collagen production by fibroblasts and to increase their proliferation in vivo and in vitro.40,41 This mechanism can be useful for stretch mark treatments, but further investigations and studies are required to prove such theory.
Trichloroacetic acid (TCA; 10–35%) has been used for many years and is safe to use at low concentrations. At higher concentrations (e.g., ≥50%), TCA has a tendency to scar and is less manageable than other agents used for superficial peels. TCA is found in several proprietary peels at varying concentrations, and some kits have instructions and buffering agents so that the peel can be diluted as deemed necessary. Anecdotal reports have indicated the use of TCA in stretch marks, although there is a lack of clarity and absence of data for assessment of this subject. Some authors have had good success using low concentrations (15–20%) of TCA and performing repetitive papillary dermis-level chemexfoliation repeated at monthly intervals with reported improvement in texture and color of marks.42,43
Glycolic acid (GA) is an alpha hydroxyl acid. Although there are several reports on the clinical effects of GA in rejuvenation, peeling, and photoaging, no data on the effectiveness of GA to prevent stretch marks could be found in the scientific literature. No epidemiological study on the use of GA in pregnant women has been published. One study comparing topical 20% GA and 0.05% tretinoin with 20% GA and 10%l-ascorbic acid found that both regimens improved the appearance of striae alba and showed no difference in effect from combining 10% ascorbic acid or 0.05% tretinoin with 20% GA, although it was not determined which of the ingredients provided the effect.39 The precise mechanism of action of GA is still unknown because the biological effects of GA on cells has not been fully studied, although GA is reported to stimulate collagen production by fibroblasts and to increase their proliferation in vivo and in vitro.40,41 This mechanism can be useful for stretch mark treatments, but further investigations and studies are required to prove such theory.Trichloroacetic acid (TCA; 10–35%) has been used for many years and is safe to use at low concentrations. At higher concentrations (e.g., ≥50%), TCA has a tendency to scar and is less manageable than other agents used for superficial peels. TCA is found in several proprietary peels at varying concentrations, and some kits have instructions and buffering agents so that the peel can be diluted as deemed necessary. Anecdotal reports have indicated the use of TCA in stretch marks, although there is a lack of clarity and absence of data for assessment of this subject. Some authors have had good success using low concentrations (15–20%) of TCA and performing repetitive papillary dermis-level chemexfoliation repeated at monthly intervals with reported improvement in texture and color of marks.42,43
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