: For both applications, a positive response of 7% for kojic acid treatment and 10% for hydroquinone
treatment were seen one month after beginning the treatment. After two months, a positive response of 24% for kojic
acid and 22% for hydroquinone was observed. The differences were not statistically significant between two groups
after 2 months, but statistical significance was seen after 3 months, with positive responses of 58% for kojic acid
and 30% for hydroquinone