Association between antidepressant use in pregnancy and adverse
birth outcomes
3.1.1. LBW
Fifteen studies evaluated the association between antenatal
antidepressant use and LBW with RRs ranging from 0.62 to 8.33
(Table 2). Using the random-effects model, antenatal antidepressant
exposure was significantly associated with LBW (RR=1.44, 95% CI:
1.21–1.70). Nine of the studies found no significant association.
Significant heterogeneity across studies was noted