Effects of the aqueous extract of C. longa on the
duration of immobility time in the mouse tail suspension
test
Effects of oral administration of the aqueous extract
of C. longa and fluoxetine on the duration of immobility
in the mouse tail suspension test were shown in Table 1.
The extract showed no any change after 1 day treatment,
and had the tendency to reduce the immobility
time after 7-day treatment. After a 14-day treatment, the
extracts at the doses of 140, 280 and 560 mg/kg
significantly decreased the duration of immobility in a
dose-dependent manner, resulting in 35.6, 40.8 and
58.1% immobility reduction, respectively. However, the
reference antidepressant fluoxetine at the dose of 20 mg/
kg resulted in significant reduction. The effects of C.
longa at the doses of 280 and 560 mg/kg appeared to be
more potent than that of fluoxetine after 14-day
treatment in the study.