Liver disease is progressive in response to chronic liver injury. This progression results in irreversible scarring and nodularity of the liver. This change in liver parenchyma interferes with blood flow through the liver, disrupting its biochemical function.
End-stage liver disease results in a hyper dynamic circulation characterized by a decrease in arterial BP, and an increase in cardiac output and heart rate. This results in diminished renal blood flow and stimulation of the renin-angiotensin-aldosterone system, sympathetic nervous system, and antidiuretic hormone, leading to renal artery vasoconstriction, sodium retention, and volume expansion.
Liver disease is progressive in response to chronic liver injury. This progression results in irreversible scarring and nodularity of the liver. This change in liver parenchyma interferes with blood flow through the liver, disrupting its biochemical function. End-stage liver disease results in a hyper dynamic circulation characterized by a decrease in arterial BP, and an increase in cardiac output and heart rate. This results in diminished renal blood flow and stimulation of the renin-angiotensin-aldosterone system, sympathetic nervous system, and antidiuretic hormone, leading to renal artery vasoconstriction, sodium retention, and volume expansion.
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