Clays function as Brønsted and/or Lewis acids, or as bases. Clays with combined acidic and basic properties have been developed by simple procedures of modification. Such clays are employed to catalyze a sequence of acid and base-catalyzed reactions in one pot. Good enantioselectivity and stereoselectivity are achieved using chiral organic compounds and chiral complexes intercalated between clay layers. Examples from recent literature are described here