Recent case reports have pointed towards triazoles as an adjunct to biguanide and diamidine therapy in refractory cases. Conventionally used as antifungals, they have been used empirically in AK. Bang et al. [34] reported in 2009 a marked improvement in three eyes treated with topical voriconazole 1% drops in addition to standard therapy. Tu et al. [35] found similarly promising results in 2010 using oral voriconazole 200 mg twice daily, but noted that extended duration treatment was required in order to prevent relapse.