Table 3 shows the total count of the two probiotic strains and SYNBIO® during the fermentation in whole milk containing oat bran and buckwheat flour at three different concentrations. Overall, the presence of buckwheat flour and oat bran in milk improved the bacterial counts. In particular, L. rhamnosus IMC 501® counts were significantly higher with respect to the control with 6% BF and 2, 4 and 6% OB while L. paracasei IMC 502® was significantly affected by both substrates and for all the concentrations. The same behavior was observed for SYNBIO® counts except for OB 2% that did not give significant results. In general, SYNBIO® combination gave good results of growth in whole milk with respect to the single strains