3.7. Clonidine-induced hypothermia
Clonidine induced hypothermia in vehicle-treated mice.
The peak effect was observed 60 min after clonidine. The
CT per se was without any effect on the rectal temperature.
Piracetam and CT did not significantly altered clonidine-induced
hypothermia. The observations are given in
Table 7.
3.8. Sodium nitrite-induced respiratory arrest
The mice treated with sodium nitrite died after 19.75 ±
0.85 min of its administration, whereas death occurred after
15.3 ± 0.41 and 16.71 ± 2.51 min in the CT- and piracetamtreated
mice. The effects of CT and piracetam were not significant
( P=.158).
3.9. Haloperidol-induced catalepsy
The haloperidol-induced catalepsy was measured until
150 min after haloperidol. The maximum catalepsy was
noted 60 min after haloperidol. The intensity of catalepsy
was more prominent in the group that received CT before
haloperidol. In CT-treated group, maximum catalepsy was
noted 45 min after haloperidol. The CT potentiated haloperidol-induced
catalepsy only unto 45 min. However, after
normalization of data (converting to ln) as suggested by
Ferre et al. (1990), the difference between the effects
produced by vehicle and CT were not significantly different.
CT alone was without any cataleptic activity. The observations
are given in Table 8.