Electron micrographs of 2-month-old diabetic (A–C) and control (F) rat retina. (A) Dense accumulations of glycogen (arrows) in the
perinuclear cytoplasm of an amacrine cell (Ac) at the interface of the INL and IPL; scale bar: 2 lm. (B) Adjacent amacrine cell shows a glycogenfilled
(arrows) saccular distension of the cell soma at the pole of the cell facing the INL; scale bar: 1 lm. The large confluent glycogen masses show
artifactual fracturing and vacuolation (A, B). (C) Less confluent glycogen deposition (G) demonstrates the ultrastructural features of discrete betaparticles
(inset); scale bar (main): 200 nm, scale bar (inset): 100 nm. (D) Dense mass of glycogen fills a presumptive amacrine process (arrow) in
IPL proximal to an Ac body with obvious masses of glycogen adjacent to the Golgi apparatus (Go); scale bar: 1 lm. (E) Amacrine cell with
perinuclear glycogen masses (G) shows a major vertically orientated cell process within IPL (arrows); scale bar: 1 lm. (F) Small aggregates of
glycogen particles (thick arrows and inset) are present in an amacrine cell of control retina. The cell containing the glycogen has a smooth nuclear
profile, similar to those showing glycogen storage in the diabetic retinas; scale bar: 1 lm.