summarizes LR, LOD, R2 ,EF ,RSD% ,and extraction time of some analytical methods along with the proposed method. In comparison to the other methods for the determination of amantadine. The proposed method shows high EF, good LR, relatively low LOD , and good precision. It should be noted that in the case of 7th and 8th methods, mass spectrometry was used as detection system which is inherently more sensitive than FID. As detection system which is inherently more sensitive than FID. Compared with LLE, the present method consumes less sample and organic solvents