The distribution of subjects has been reclassified according to the new 2011 GOLD criteria, which additionally includes CAT scores and frequency of exacerbation. As time progressed from enrollment to the prospective results, 156 subjects (17.0%) became more symptomatic and/or high risk, but 137 subjects (15.0%) became less symptomatic and/or low risk. A further study will be required to investigate this difference.