Flouroquinolone antibiotics are a class of compound widely used as broad- spectrum
antimicrobial agents in clinical treatment, but these drugs are also well known to exhibit
phototoxic, photomutagenic and photocarcinogenic properties [3]. Prulifloxacin (PLF,1), a novel
fluroquinolone posses phototosensitizing properties that lead to phototoxic responses in both
human and animal subjects [4].It is an antibacterial drug contains a thiazeto-quinolone skeleton
with a four-member ring in the 1,2 position. Following oral administration, the drug is