prevent formation of AGEs, however, indicating that it
prevents oxidative modification of lipid independent of any
effect on advanced glycosylation.
AGE formation generally follows complex, higher-order
reaction kinetics that reflect in part the generation ofreactive
intermediates, which produce AGEs at a faster rate than the
starting reactant, glucose (13, 14). Curvilinear, time- and
concentration-dependent increases in advanced glycosylation
occur when glucose reacts with protein or amino acids.
Similar curvilinear increases in the formation of AGEs were
observed by incubating glucose with PE (Fig. 2). Logarithmic
transformation of measurements that were obtained with PE
and increasing glucose concentrations demonstrated that
four measured reaction products: chromophores, fluoro-