Findings: A total of 593 patients(intention-to-treat population)were enrolled:63.1%were male;their mean (SD)age was38.4 (11.8)years;and 78.6%had paranoid schizophrenia.The main reasons for transition to PP were patient’s wish(n ¼ 259 [43.7%]), lack of efficacy (n ¼ 144 [24.3%]),