Treatment of lupus nephritis consists of 2 phases: induction and maintenance. There is some controversy as to what agent should be used due to issues with the individual agents and limited data, particularly with maintenance therapy. Selection of the appropriate agent depends on the severity of disease, risk of adverse reactions with the different medications, desire to preserve fertility, and cost. Typically, patients will be started on a regimen of IV cyclophosphamide plus corticosteroids or mycophenolate mofetil. Meta-analyses of lupus nephritis therapies have generally shown that there is similar efficacy between mycophenolate mofetil and cyclophosphamide for induction therapy. Studies included in these analyses generally lasted between 6 and 12 months.