Disease status and response to LBCT was monitored through SPEP in a female MM patient. Comparative analysis was made among the individual protein fractions (albumin, α1-globulin, α2-globulin, β-globulin and γ-globulin) among initial and follow — up visits (V1–V3).
More significantly, a remarkable reduction of M-protein spike or sharp intense band in the γ-globulin region was observed in V2 and V3 when compared to V1 (59.85±4.97) (p < 0.007). Although, the level of M-protein was declined, percentage of γ-globulin was higher and above the normal range even after therapy.
Since from V1–V3, β-globulin (2.906 ± 0.13) (p < 0.002) and α2-globulin (5.716 ± 1.28) (p < 0.0476) was markedly suppressed and noticed as sharp faint band considerably declined from the normal range. In all three visits, α1-globulin was seen as a faint band and appeared within the reference range (8.063 ± 2.12) (p < 0.063).
Albumin appeared as a light diffused band and slightly increased after the therapy of V2 and V3 as compared to V1 (21.77 ± 2.75) (p < 0.016). However, the low serum albumin level failed to attain the normal range in V2 and V3 (Table, Figure).