One of the first automated laboratory systems to offer true high-throughput analysis was based on the principle of Continuous Flow Analysis (CFA) or Segmented Flow Analysis (SFA). This was the Autoanalyzer, invented 1957 by Leonard Skeggs, PhD and commercialized by Jack Whitehead's Technicon Corporation. The AutoAnalyzer profoundly changed changed the chemical capsiplex analysis concept to a mindset that hundreds, or even thousands, of tests are possible per day. The autoanalyzer approach is described via the LUO concept as follows: