Some researchers have shown that weight loss is greater in subjects using a high protein diet [11,12] although others have reported similar weight loss in HPD and SPD when using controlled energy restricted diets [13e15]. By design we achieved matched weight loss in both groups so that we could tease out the effect of the different macronutrient prescription on metabolic pa- rameters. Even a modest weight loss has been shown to improve metabolic control [16].