Figure 2
Relative changes in quenching rate as a function of alcohol concentration. Results are shown for (A) straight-chain alcohols (methanol through 1-decanol) and (B) 1-pentanol, 2-pentanol, and 3-pentanol. Each alcohol was tested on at least three different ...
For each alcohol, a straight line (f([alc]) = 1 + [alc]/D) is fit to the results to determine the [alc] needed to double the quenching rate (D) as a measure of the alcohol's bilayer-modifying potency. Fig. 3 A shows D for all of the alcohols tested (using this experimental design). Similarly to the dose-response curves (Fig. 2 and Fig. S1), D shows the same logarithmic decrease (increase in potency) as a function of chain length for the shorter alcohols, with a gradual leveling off at longer chain lengths. Except for nonanol and decanol, the straight-chain variants are more potent than their branched counterparts.