The results of this study lay the groundwork for improvements in irrigation practices in northeast Louisiana and the Mississippi Delta. The ETc values obtained from this study provide a knowledge base of cotton water use under local environmental conditions that will have value for irrigation and research purposes. Kc-ini-local was 0.42 in both years, Kc-mid-local ranged from 1.06 in 2011 to 1.44 in 2010, and Kc-end-local ranged from 0.62 in 2010 to 0.78 in 2011. These values provide a basis for the development of Kc-based irrigation scheduling in the region.