Surface topography is one of the key factors affecting protein absorption
and cellular behavior on artificial materials and consequently invivo
performances of implants . It was reported that the primary implant
fixation is strongly affected by the design and macro-scale features
of the implant, while micro- and nano-features affect cell response.
They control the cell recruitment, adhesion, orientation, morphology,
focal contact formation, cytoskeletal organization and even gene
expression. Moreover, protein absorption and conformation are also modulated by surface nanoroughness. In addition, nanoroughness
does not increase the risk of bacterial contamination