pulsed-field gel electrophoresis, enabled rapid early progress. Therefore, the 1990 plan was updated with a new five-year plan announced in 1993 in the journal Science (262: 43-46; 1993).
Indeed, a large part of the early work of the HGP was devoted to the development of improved technologies for accelerating the elucidation of the genome. In a 2001 article in the journal Genome Research, Collins wrote, "Building detailed genetic and physical maps, developing better, cheaper and faster technologies for handling DNA, and mapping and sequencing the more modest-sized genomes of model organisms were all critical stepping stones on the path to initiating the large-scale sequencing of the human genome.